Back Posted: Oct 14 2025

Bioanalytical Principal Scientist

M60, Manchester , United Kingdom

Health Care & Medicine jobs >> Pharmaceutical

Negotiable

Permanent

Name Confidential

Description

Job Title: Principal Bioanalytical Scientist (Small Molecule Bioanalysis)
Location: Manchester
Company: A leading Bioanalytical CRO
Employment Type: Full-time, Permanent

About the Company

Our client is a well-established bioanalytical Contract Research Organization (CRO) supporting pharmaceutical and biotechnology partners in drug discovery and development. The principal bioanalytical scientist will be a specialist in LC-MS/MS bioanalysis, providing high-quality analytical services for small molecules, peptides, and biotherapeutics across all stages of development.

This is a senior technical position focused on LC-MS/MS method development, validation, and scientific oversight of bioanalytical studies and teams. The client has already got career development paths in place to support progression into senior management positions.

Key Responsibilities

* Lead LC-MS/MS method development and validation for quantitative bioanalysis of small molecules in biological matrices (e.g., plasma, serum, urine, tissues).

* Serve as technical lead for multiple client studies, overseeing project design, troubleshooting, and scientific interpretation.

* Provide expert input on bioanalytical strategy, assay design, and regulatory compliance (FDA/EMA guidelines).

* Communicate effectively with clients to explain methods, justify scientific approaches, and provide project updates.

* Support technical proposal writing and contribute to pre-sales scientific discussions.

* Mentor and support junior scientists in method development, validation, and sample analysis.

* Review and interpret complex data, ensuring scientific integrity and consistency across reports.

* Contribute to departmental process improvements, instrumentation upgrades, and technical innovation.

Key Skills & Experience

* Significant experience in LC-MS/MS method development and validation for small molecule bioanalysis in biological matrices.

* Excellent understanding of regulatory expectations for bioanalytical method validation (FDA, EMA, ICH).

* Proven ability to independently manage and deliver complex client projects in a CRO or pharmaceutical environment.

* Strong communication skills with experience presenting and defending technical work to clients.

* Experience with peptides, proteins, or oligonucleotides is advantageous.

* Highly organized, detail-oriented, and able to manage multiple projects simultaneously.

* Collaborative mindset with the ability to work effectively across scientific and project teams.

Qualifications

* Degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline (PhD, MSc, or equivalent).

* Experience in bioanalytical LC-MS/MS within a CRO or pharma setting.

Why Join

* Join a scientifically driven, collaborative CRO environment.

* Work on diverse and technically challenging bioanalytical projects.

* Direct influence on scientific decisions and client relationships.

* Competitive salary (£45,000 to £60,000) benefits, relocation package and strong career development opportunities.

Should you be suitable apply and I am able to disclose full details, including Company, Salary and Location

No. of positions available*: 1
Salary: Negotiable
Experience: None
Education: None
Post Date: October 14, 2025
Job id:. CV-181278
Position Type: Permanent
Applicants: 0
Views: 9

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